Birth process
Monday, October 31st, 2005Boring people language:
Stage 1: Cleavage
After fertilisation, the zygote undergoes a series of mitotic division to form a ball of cells (morula). Each cell in the morula is known as a blastomere. The blastomeres in the centre of the morula secrete a fluid which would cause the formation of a cavity which is known as the blastocoel. At this stage, the embryo is known as a blastula. The pattern of cleavage is influenced by the amount of yolk and its location in the cell. In mammals, the yolk is fairly evenly distributed. However, cleavage in mammalian blastula would cause the formation of an inner cell mass which develops into the embryo, and an outer cell mass - known as trophoblast - will contribute to the development of the placenta.
Stage 2: Gastrulation
One side of the blastula will form an indentation, due to the the invagination of the cells. In aquatic vertebrates, the invagination will go to the extent of obliterating the blastocoel altogether. The invagination will eventually form a new cavity - the archenteron. The layer of cells that line the archenteron is known as the endoderm, while the remaining layer of cells outside is known as the ectoderm. Some cells migrate between the endoderm and the ectoderm, forming the mesoderm. Gastrulation is complete once these three layers of cells are formed.
Stage 3: Organogenesis
One part of the mesoderm will differentiate into the notochord - a cartilage-like tissue which functions much as a supporting rod. The ectoderm just above will proliferate, thicken and differentiate into the neural plate - the base for the formation of the central nervous system. The neural plate grows inwards, forming the neural groove. The ends of the neural groove grow towards each other and fuse together, forming the neural tube. The remaining mesoderm, endoderm and ectoderm will develop into various organs; the endoderm mainly develops into the digestive system, the ectoderm into sensory organs and epidermis, and the mesoderm into the dermis of the skin and the central nervous system.
Birth process in humans
Stage 1: Dilation
As a preparation for birth, the fetus turns so that its head is towards the cervix. Oestrogen levels are high and progesterone levels plummet. High levels of oestrogen raises the sensitivity of the myometrium towards oxytocin. Low levels of progesterone will remove the inhibition of uterine contraction caused by high levels of progesterone. The fetal pituitary gland will secrete adrenocorticotrophic hormone (ACTH). ACTH acts to stimulate the maternal adrenal glands to release corticosteroid. Corticosteroid has two functions: firstly, it further inhibits the secretion of progesterone. Low levels of progesterone will induce the secretion of oxytosin by the maternal posterior pituitary gland. Corticosteroid also stimulates the releasing of prostaglandin by the placenta. Low levels of progesterone and the presence of oxytosin induces uterine contraction. Prostaglandin functions by strengthening the effect of oxytosin. The action of uterine contraction activates a positive feedback mechanism, which causes the secretion of more and more oxytosin which in turn results in increasingly stronger contractions. The dilation stage ends when the cervix is dilated (due to the pressure exerted by the fetus) to about 10 cm wide.
Stage 2: Parturition
Stage 2 is initiated when the amniotic sac bursts, causing the amniotic fluid to flow out. The fetus’ head continues to exert pressure (to the bladder and rectum), stimulating the mother to ‘push’. The fetus usually emerges headfirst, followed by the shoulder, torso, buttocks and finally the legs. About 3%-4% of fetus comes out feetfirst - this inverted order is dubbed "breech birth". Parturition ends when the whole fetus emerges.
Stage 3: Placental stage
The uterus continues to contract, though not so strongly, even after the fetus has been expelled. These contactions would finally force the placenta and the umbillical chord out. Following the removal of the placenta, oestrogen and progesterone levels drop drastically - so as to disallow inhibition of the secretion of prolactin by the pituitary glands. Prolactin is vital in its role to stimulate milk production at the mammory glands.
Layman’s language: Shag till she gets pregnant, after +-9 months give birth to a whole new world of headache.
My memory has served me well. I have succesfully memorized 1% of the entire syllabus (This is one subtopic out of like 7 subtopics in this chapter. There are 25 chapters. This is NOT the longest chapter). If anyone cared to read at all, feel free to correct any mistakes.
Well… since I cannot tear myself away from the computer, might as well kill two birds with one stone right. Do revision WITH the computer.
Damn, I’m pathetic.